When one is forced to act in a way which is forbidden, or to refrain from acting in a way which is proper, he becomes regretful and thinks himself dishonored. At that time there is a sense of disappointment. In this kind of disappointment one becomes full of anxiety, sheds tears, changes bodily color, feels humility and breathes heavily.
When Kṛṣṇa, in punishing the Kāliya serpent, appeared to have drowned Himself in the poisonous water of the Yamunā, Nanda Mahārāj addressed Yaśodā Devī thusly: "My dear wife, Kṛṣṇa has gone deep into the water, and so there is no longer any need to maintain our bodies, which are so full of sinful activities! Let us also enter into the poisonous water of the Yamunā and compensate for the sinful activities of our lives!" This is an instance of severe shock, where the devotee becomes greatly disappointed.
When Kṛṣṇa left Vṛndāvana, Subala, His intimate friend, decided to leave also. While leaving, Subala was contemplating that without Kṛṣṇa there was no longer any pleasure to be found in Vṛndāvana. The analogy is given that, as the bees go away from a flower that has no honey, so Subala left Vṛndāvana when he found there was no longer any relishable transcendental pleasure there.
In Dāna-keli-kaumudī Śrīmatī Rādhārāṇī addresses one of Her friends in this manner: "My dear friend, if I cannot hear of the glorious activities of Kṛṣṇa, it is better for Me to become deaf. And because I am now unable to see Him, it would be good for Me to be a blind woman." This is another instance of disappointment due to separation from Kṛṣṇa.