When a person blames himself for committing an inappropriate action, his feeling is called guilt.
One day Śrīmatī Rādhārāṇī was churning yogurt for Kṛṣṇa. At that time the jeweled bangles on Her hands were circling around, and She was also chanting the holy name of Kṛṣṇa. All of a sudden She thought, "I am chanting the holy name of Kṛṣṇa, and My superiors—My mother-in-law and My sister-in-law—may hear Me!" By this thought Rādhārāṇī became overanxious. This is an instance of feeling guilty because of devotion to Kṛṣṇa.
One day the beautiful-eyed Śrīmatī Rādhārāṇī entered into the forest to collect some flowers to prepare a garland for Kṛṣṇa. While collecting the flowers, She became afraid that someone might see Her, and She felt some fatigue and weakness. This is an instance of guilty feelings caused by labor for Kṛṣṇa.
There is a statement in Rasa-sudhākara that after passing the night with Kṛṣṇa, Rādhārāṇī became so weak that She was unable to get up from bed. When Kṛṣṇa took Her hand to help Her, Rādhārāṇī felt guilty about having passed the night with Him.