When Kṛṣṇa was absent from Vṛndāvana and was staying at Mathurā, some of His friends informed Him, "Dear Kṛṣṇa, because of their separation from You, the inhabitants of Vraja are so afflicted that they appear to be diseased. Their bodies are feverish, and they cannot move properly. They are simply lying down on the ground and breathing heavily."
In the Tenth Canto, Twelfth Chapter, verse 44, of Śrīmad-Bhāgavatam, Mahārāja Parīkṣit asked about Lord Ananta, and upon hearing this question, Śukadeva Gosvāmī began to show symptoms of collapsing. Yet he checked himself and answered King Parīkṣit's question in a mild voice. This collapsing condition is described as a feverish state resulting from ecstatic pleasure.
There is another statement in Śrīmad-Bhāgavatam telling of the damsels of Vraja meeting Kṛṣṇa at the sacred place of Kurukṣetra, many years after their childhood pastimes. When they met in that sacred place, all the gopīs became stunned by the occurrence of a solar eclipse. Their breathing, blinking of the eyes and all similar activities stopped, and they stood before Kṛṣṇa just like statues. This is another instance of a diseased condition resulting from exuberant transcendental pleasure.