"The sixteen words Hare Kṛṣṇa, Hare Kṛṣṇa, Kṛṣṇa Kṛṣṇa, Hare Hare/ Hare Rāma, Hare Rāma, Rāma Rāma, Hare Hare are especially meant for counteracting the contaminations of Kali. To save oneself from the contamination of Kali, there is no alternative to the chanting of these sixteen words."
Lord Caitanya informed Prakāśānanda Sarasvatī that when His spiritual master understood Him he said, "It is the transcendental nature of the holy names Hare Kṛṣṇa, Hare Kṛṣṇa, Kṛṣṇa Kṛṣṇa, Hare Hare/ Hare Rāma, Hare Rāma, Rāma Rāma, Hare Hare to transport a man into spiritual madness. Anyone who sincerely chants this holy name is quickly elevated to the platform of love of God and becomes mad after God. This madness arising from love of God is the highest perfectional stage for a human being."
Generally a human being is interested in religion, economic development, sense gratification and liberation. But love of God is above all these. A bona fide spiritual master chants the holy names Hare Kṛṣṇa, Hare Kṛṣṇa, Kṛṣṇa Kṛṣṇa, Hare Hare/ Hare Rāma, Hare Rāma, Rāma Rāma, Hare Hare, and the transcendental sound vibration enters the ear of the disciple, and if the disciple follows in the footsteps of his spiritual master and chants the holy name with similar respect, this chanting constitutes worship of the transcendental name. When the transcendental name is worshiped by the devotee, the name Himself spreads His glories within the heart of the devotee. When the devotee is perfectly qualified in chanting the transcendental vibration of the holy name, he is quite fit to become a spiritual master and to deliver all the people of the world. The chanting of the holy name is so powerful that it gradually establishes its supremacy above everything in the world. The devotee who chants it becomes transcendentally situated in ecstasy and sometimes laughs, cries and dances in his ecstasy. Sometimes the unintelligent put hindrances in the path of the chanting of the Hare Kṛṣṇa mahā-mantra, but one who is situated on the platform of love of Godhead continues to chant the holy name loudly for the benefit of all concerned. As a result, everyone becomes initiated into the chanting of the holy names—Hare Kṛṣṇa, Hare Kṛṣṇa, Kṛṣṇa Kṛṣṇa, Hare Hare/ Hare Rāma, Hare Rāma, Rāma Rāma, Hare Hare. By chanting and hearing the holy names of Kṛṣṇa, a person can remember the forms and qualities of Kṛṣṇa.