When Kṛṣṇa left Vṛndāvana, Subala, His intimate friend, decided to leave also. While leaving, Subala was contemplating that without Kṛṣṇa there was no longer any pleasure to be found in Vṛndāvana. The analogy is given that, as the bees go away from a flower that has no honey, so Subala left Vṛndāvana when he found there was no longer any relishable transcendental pleasure there.
In Dāna-keli-kaumudī Śrīmatī Rādhārāṇī addresses one of Her friends in this manner: "My dear friend, if I cannot hear of the glorious activities of Kṛṣṇa, it is better for Me to become deaf. And because I am now unable to see Him, it would be good for Me to be a blind woman." This is another instance of disappointment due to separation from Kṛṣṇa.
There is a statement in the Hari-vaṁśa wherein Satyabhāmā, one of the queens of Kṛṣṇa in Dvārakā, tells her husband: "My dear Kṛṣṇa, since I heard Nārada glorifying Rukmiṇī before You, I can understand that there is no need of any talking about myself." This is an instance of disappointment caused by envy. Rukmiṇī and Satyabhāmā were co-wives, and because Kṛṣṇa was husband of both, there naturally was some feminine envy between them. So when Satyabhāmā heard the glories of Rukmiṇī, she was envious of her and thus became disappointed.
In the Tenth Canto, 51st Chapter, 29th verse of Śrīmad-Bhāgavatam there is this statement: "My dear Kṛṣṇa, I cannot say that it is only other people who are implicated in material existence, because I too am much entangled with the bodily concept of life. I am always too anxious about my family, home, wife, wealth, land and kingdom. And because I have been so maddened by this material atmosphere, I am thinking now that my life has been simply spoiled." This statement is an instance of disappointment caused by lamentation.
According to Bharata Muni, this disappointment is inauspicious. But there are other learned scholars who have accepted such disappointment as being in the mood of neutrality and as being a preservative for ecstatic love.