The threefold miseries is summarized in Bhagavad-gītā by four principles: janma-mṛtyu-jarā-vyādhi-duḥkha-doṣānudarśanam (BG 13.9).
If a man is actually learned and intelligent, he should always see before him that there are four kinds of distresses. What is that? The distress of taking birth, the distress of dying procedure, janma-mṛtyu, and distress of old age and distress of diseases.
So we are very much proud of our advancement of knowledge, but actually there is no solution for these four principles of miseries. There is no remedy. They are trying to control birth rate, janma, but still, every minute there are increasing, the population of world is increasing.
Similarly, they are trying to save people from death, but still, people are dying in hundreds and thousands. And they are trying to get out of this old age—so many medicines, so many cosmetics—but old age is taking place. And so far disease, we can discover many high-grade medicines, but there is no stoppage of disease.
So one should be very intelligent that there is no remedy for these four kinds of miseries, janma-mṛtyu-jarā-vyādhi. And a learned man should be inquisitive, "If there is any remedy?" So Sanātana Gosvāmī is presenting himself before Lord Caitanya that, "People say that I am very learned man. But I am so learned man that I do not know what I am and why I am suffering from these miseries, although I do not like to suffer."
Go on.
Lady devotee: " 'I do not know how to question You about the advancement of spiritual life, but I beg that You kindly, mercifully, let me know everything that I should know.' This is the process of acceptance of a spiritual master by the disciple. One should approach a spiritual master and humbly submit to him and then inquire from him about one's spiritual progress. The Lord was pleased by Sanātana's submissive behavior, and He replied as follows: 'You have already received benediction from Lord Kṛṣṇa.' "
Prabhupāda: Here . . . here is another point, that Sanātana Gosvāmī approached his spiritual master, Lord Caitanya, and he submitted himself in such a way that his spiritual master, Lord Caitanya, was very pleased. So that should be the point of disciples: how to please the spiritual master. And Viśvanātha Cakravartī Ṭhākura, he has composed eight stanzas as prayers of spiritual master.
And in the seventh stanza he says, yasya prasādād bhagavat-prasādaḥ, if you can please your spiritual master, then you know that God, or Kṛṣṇa, is pleased. Yasya prasādād bhagavat-prasādo yasyaprasādān na gatiḥ kuto 'pi. And if you cannot please your spiritual master, then you must know that you do not know your whereabouts; you do not know where you are going.
So Sanātana Gosvāmī was actually following the disciplic principles. He wanted to please Lord Caitanya submissively. To please the spiritual master means to approach him submissively, not in a challenging mood.