After the passing away of Śrī Caitanya Mahāprabhu and Svarūpa Dāmodara, Raghunātha dāsa, unable to bear the pain of separation from these objects of his complete devotion, traveled to Vṛndāvana, intending to commit suicide by jumping from Govardhana Hill. In Vṛndāvana, however, he encountered Śrīla Rūpa Gosvāmī and Śrīla Sanātana Gosvāmī, two of the most confidential disciples of Caitanya Mahāprabhu. They convinced him to give up his planned suicide and impelled him to reveal to them the spiritually inspiring events of Lord Caitanya's later life. Kṛṣṇadāsa Kavirāja Gosvāmī was also residing in Vṛndāvana at this time, and Raghunātha dāsa Gosvāmī endowed him with a full comprehension of the transcendental life of Śrī Caitanya Mahāprabhu.
By this time, contemporary and near-contemporary scholars and devotees had already written several biographical works on the life of Śrī Kṛṣṇa Caitanya Mahāprabhu. These included Śrī Caitanya-carita, by Murāri Gupta, Caitanya-maṅgala, by Locana dāsa Ṭhākura, and Caitanya-bhāgavata. This latter work, by Vṛndāvana dāsa Ṭhākura, who was then considered the principal authority on Śrī Caitanya's life, was highly revered. While composing his important work, Vṛndāvana dāsa, fearing that it would become too voluminous, avoided elaborately describing many of the events of Śrī Caitanya Mahāprabhu's life, particularly the later ones. Anxious to hear of these later pastimes, the devotees in Vṛndāvana requested Kṛṣṇadāsa Kavirāja Gosvāmī, whom they respected as a great saint and scholar, to compose a book narrating these episodes in detail. Upon this request, and with the permission and blessings of the Madana-mohana Deity of Vṛndāvana, he began compiling Śrī Caitanya-caritāmṛta, which, due to its literary excellence and philosophical thoroughness, is today universally regarded as the foremost work on the life and profound teachings of Śrī Caitanya Mahāprabhu.