That is called jñānāvasthita-cetasaḥ. Ignorant person, they suffer from disease, they suffer from legal action, because ignorant.
Ignorance is no law, no excuse. If you go to the court, "Sir, I did not know this law. I did not know law that 'Keep to the left,' " so the court will not excuse you. "I did not know that to associate with the smallpox infection." The nature will not excuse you. A child touches fire. The fire will not excuse, "Because it is a child, no, no, I shall not burn it." No. Nature must work. Daivī hy eṣā guṇa-mayī mama māyā duratyayā (BG 7.14).
So you have to be fully in knowledge how to save yourself from the contamination of the modes of material nature. That is called gata-saṅgasya muktasya. Then you are free. So that is also stated, how you can become gata-saṅgasya. That is stated in the Bhagavad-gītā.