He was now so renowned that He was considered to be the best paṇḍita in Nadia. Keśava Miśra of Kashmir, who had called himself the Great Digvijayī (world conqueror), came to Nadia with a view to debate the paṇḍitas of that place. Afraid of the so-called conquering paṇḍita, the tola professors of Nadia left their town on the pretense of invitation. Keśava met Mahāprabhu at the Barokona-ghāṭā in Māyāpur, and after a very short discussion with Him he was defeated by the boy, and mortification obliged him to decamp. Nimāi Paṇḍita was now the most important paṇḍita of His times.
It was at the age of sixteen or seventeen that He traveled to Gayā with a host of His students and there took His spiritual initiation from Īśvara Purī, a Vaiṣṇava sannyāsī and a disciple of the renowned Mādhavendra Purī. Upon His return to Nadia, Nimāi Paṇḍita turned religious preacher, and His religious nature became so strongly represented that Advaita Prabhu, Śrīvāsa and others who had before the birth of Caitanya already accepted the Vaiṣṇava faith were astonished at the change in the young man. He was then no more a contending naiyāyika, a wrangling smārta and a criticizing rhetorician. He swooned at the name of Kṛṣṇa and behaved as an inspired man under the influence of His religious sentiment. It has been described by Murāri Gupta, an eyewitness, that He showed His heavenly powers in the house of Śrīvāsa Paṇḍita in the presence of hundreds of His followers, who were mostly well-read scholars.