We are very much proud of our advancement of knowledge, but actually there is no solution for these four principles of miseries. There is no remedy. They are trying to control birth rate, janma, but still, every minute there are increasing, the population of world is increasing.
Similarly, they are trying to save people from death, but still, people are dying in hundreds and thousands. And they are trying to get out of this old age—so many medicines, so many cosmetics—but old age is taking place. And so far disease, we can discover many high-grade medicines, but there is no stoppage of disease.
So one should be very intelligent that there is no remedy for these four kinds of miseries, janma-mṛtyu-jarā-vyādhi. And a learned man should be inquisitive, "If there is any remedy?" So Sanātana Gosvāmī is presenting himself before Lord Caitanya that, "People say that I am very learned man. But I am so learned man that I do not know what I am and why I am suffering from these miseries, although I do not like to suffer."