When Kṛṣṇa was absent from Vṛndāvana and was staying in Mathurā, Śrīmatī Rādhārāṇī sent news to Him that His mother, the Queen of Braja, was feeling such separation from Him that there was foam coming from her mouth, like the foam on the shore of the ocean. And sometimes she was raising her arms like the waves of the ocean, and because of her intense feelings of separation, she was rolling on the ground and creating a tumultuous roaring sound. And sometimes she was remaining completely silent, like a calm sea. These symptoms of separation from Kṛṣṇa are called apasmāra, or forgetfulness. One completely forgets his position when he manifests these symptoms in ecstatic love.
Another message was once sent to Kṛṣṇa informing Him that after He had killed Kaṁsa, one of Kaṁsa's demon friends had gone insane. This demon was foaming at the mouth, waving his arms and rolling on the ground. This demonic demonstration is in relationship with Kṛṣṇa in ghastly humor. This mellow or flavor is one of the indirect relationships with Kṛṣṇa. The first five kinds of relationships are called direct, and the other seven are called indirect. Some way or other, the demon must have had some relationship with Kṛṣṇa, because these symptoms developed when he heard that Kṛṣṇa had already killed Kaṁsa. Śrīla Rūpa Gosvāmī remarks that there is also transcendental excellence in this kind of symptom.
When Kṛṣṇa was absent from Vṛndāvana and was staying at Mathurā, some of His friends informed Him, "My dear Kṛṣṇa, because of their separation from You, the inhabitants of Braja are so afflicted that they appear to be diseased. Their bodies are feverish, and they cannot move properly. They are simply lying down on the ground and breathing heavily."
In the Tenth Canto, 12th Chapter, 41st verse of Śrīmad-Bhāgavatam, Mahārāj Parīkṣit asked about Lord Ananta, and upon hearing this question, Śukadeva Gosvāmī began to show symptoms of collapsing. Yet he checked himself and answered King Parīkṣit's question in a mild voice. This collapsing condition is described as a feverish state resulting from ecstatic pleasure.