Śrī Caitanya Mahāprabhu's opinion is that viṣayiṇām sandarśanaṁ atha yoṣitāṁ ca hā hanta hā hanta viṣa-bhakṣaṇato 'py asādhu (CC Madhya 11.8). Viṣayiṇāṁ sandarśanam, to mix very intimately with the viṣayīs. Viṣayī means those who are very much fond of eating, sleeping, mating and defending. They are called viṣayī. They have no other business.
So practically, at the present moment, the whole world is viṣayī. But this line, Kṛṣṇa consciousness line, is so transcendental that one has to give up this viṣayī idea. Viṣaya chāṛiyā se rase majiyā mukhe bolo hari hari (Parama Koruṇa 2). We chant "Hari, Hari," but actually, "Hari, Hari," we can chant "Hari, Hari" only when we give up viṣaya. Viṣaya chāṛiyā se rase majiyā. Otherwise, "Hari, Hari" is not purely chanted. Therefore there are ten kinds of offenses we have to give up. Śuddha-nāma. When we chant pure Hare Kṛṣṇa mahā-mantra, then we are elevated to the platform of transcendental love. Otherwise, we can attain up to liberation. Not on the platform of loving.
So Caitanya Mahāprabhu was very strict about viṣayī and strī-saṅgī. Caitanya Mahāprabhu was asked how to . . . what is the business of a Vaiṣṇava. He summarized in two lines: asat-saṅga tyāga, ei vaiṣṇava ācāra (CC Madhya 22.87). Asat-saṅga tyāga: to give up the association of asat. Asat means materialistic. So who is asat? Now, asat eka strī-saṅgī and kṛṣṇa-abhakta. Those who are too much attached for material enjoyment, they are asat. And one who is not devotee of Kṛṣṇa, he is also asat. So we have to give up the company of these kind of people, who are too much materially attached and is not devotee of Kṛṣṇa. If we can avoid these two persons, then we can be fixed up in devotional service.