He domiciled on the banks of the Ganges after marrying Śrīmatī Śacīdevī, a daughter of Śrīla Nīlāmbara Cakravartī, the great learned scholar of Navadvīpa.
Jagannātha Miśra had a number of daughters by his wife, Śrīmatī Śacīdevī, but they all expired at an early age. The two surviving sons, Śrī Viśvarūpa and Viśvambhara, became at last the object of their parental affection. The tenth child and youngest son, who was named Viśvambhara, later became known as Nimāi Paṇḍita and then, after accepting the renounced order of life, Lord Śrī Caitanya Mahāprabhu.
Lord Śrī Caitanya Mahāprabhu exhibited His transcendental activities for forty-eight years and then disappeared from this mortal world in the year 1455 Śakābda at Purī.
For His first twenty-four years He remained at Navadvīpa as a student and householder. His first wife was Śrīmatī Lakṣmīpriyā, who died at an early age when the Lord was away from home.